Nume proiect: PLASTURE TRANSDERMIC REALIZAT PRIN METODE LASER PENTRU BOLI CARDIOVASCULARE

Contract nr. 41/05.10.2011

Cod proiect: PN-II-RU-TE-2011-3-0267

Denumirea Programului din PN II: Resurse Umane

Subprogram: Proiecte de cercetare pentru stimularea constituirii de tinere echipe de cercetare independente

Autoritatea contractanta: Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (UEFISCDI)

Director de proiect: Alexandra Palla Papavlu

Coordonator: Institutul National pentru Fizica Laserilor, Plasmei si Radiatiei

Rezumat:

The new trend in the era we live, e.g. tobacco use, dietary customs, and physical inactivity is responsible for the major killers worldwide - the hypertensive heart diseases. This lead to the development of new pharmaceutical forms with improved bioavailability and stable dosage by using clean technologies. Among these, transdermal patches gained popularity, being nowadays developed for everything, i.e. from contraception to Parkinson's disease. Although significant advances have been directed towards the fabrication of transdermal patches for hypertensive heart diseases, so far the already available transdermal patches present a large series of limitations. This is due to the large number of requirements they have to fulfill: the fabrication of a drug delivery system that meets all the stringent needs specific to the drug molecule, they have to be comfortable and cosmetically appealing, scale-up and manufacturability, and most important, economical. This project, through its team of six young researchers and one senior scientist, aims at using an alternative technology (i.e. MAPLE) to prepare in a quick and one-step procedure a new generation transdermal patches with Captopril as active compound, for hypertensive heart diseases, in order to overcome its side effects by oral application. Such developments of an improved state-of-the-art transdermal patch by means of MAPLE promise to be a breakthrough in the field of medicine, biotechnology, and polymer science.

Obiectivul proiectului
Obiectivul principal al acestui proiect este de a aplica o tehnologie alternativa, MAPLE (Evaporare laser pulsate asistata de o matrice) pentru a fabrica rapid si intr-un singur pas plasturi transdermici. Acesti plasturi contin substanta activa Captopril si vor fi folositi pentru tratarea hipertensiunii arteriale.

Obiective intermediare:
Obiectivul principal al proiectului este sustinut de obiective intermediare, ce corespund fiecarui an de implementare a proiectului:
Anul I: Experimente MAPLE pentru depunerea de filme subtiri polimerice si amestecuri de polimeri. Caracterizarea chimica si morfologica a filmelor subtiri de polimeri depuse.
Anul II: Experimente MAPLE pentru depunerea de filme subtiri polimerice ce contin substanta activa Captopril. Analiza materialelor depuse (studii morfologice, aderenta, masuratori de unghi de contact, structura chimica, determinarea variatiilor de grosime si masa, determinarea incorporarii de substanta activa).
Anul III: Teste in vivo si ex vivo.


Componenta echipei de implementare
Dr. Alexandra Palla-Papavlu – director de proiect
Dr. Maria Dinescu – cercetator senior
Dr. Andreea Matei – cercetator post-doctorand
Dr. Valentina Dinca - cercetator post-doctorand
Dr. Mihaela Filipescu – cercetator post-doctorand
Dr. Catalin Luculescu – cercetator senior
Antoniu Moldovan – student doctorand

 

Diseminare
 

Publicatii:
1. A. Palla-Papavlu, J. Shaw-Stewart, T. Mattle, V. Dinca, T. Lippert, A. Wokaun, M. Dinescu, Comparison of 193 nm and 308 nm laser liquid printing by shadowgraphy imaging, Appl. Surf. Sci. Vol. 278, pages 180-184, 2013

2. M. Dinescu, A. Matei, V. Dinca, A. Palla Papavlu, F. Di Pietrantonio, D. Cannata, M. Benetti, E. Verona, T. Lippert, Laser processing of organic materials: Applications in tissue engineering and chemical sensing, Romanian Reports in Physics, Vol. 65, pp 1091-1031 (2013)

3. A. Palla Papavlu, L. Rusen, V. Dinca, M. Filipescu, T. Lippert, M. Dinescu, Characterization of ethylcellulose and hydroxypropyl methylcellulose thin films deposited by matrix-assisted pulsed laser evaporation, Applied Surface Science 302: 87-91 (2014).
 

4. A. Palla-Papavlu, M. Filipescu, I. Tirca, T. Lippert, L. Cremer, A. Calugaru, E. Vlase, C. Coman, M. Dinescu, “Captopril transdermal patches prepared via laser-assisted method” – under review


Conferinte:

No.

Conference

Title and authors

Type of presentation

1.

E-MRS, Strasbourg, Franta

14-18.05.2012

Development of a polymer patch by matrix-assisted pulsed laser evaporation as a model of transdermal sustained release system, A. Palla-Papavlu, V. Dinca, M. Filipescu, P. Rotaru, M. Dinescu

Poster

2.

New Materials and Devices Group, Polytechnic School of the University of Sao Paulo, Brazilia

14.06.2012

Laser processing of soft materials: An overview of MAPLE and LIFT, A. Palla Papavlu

Lectie invitata

3.

ROMOPTO, International Conference on Optics "Micro-to-Nano-Photonics III" Bucuresti, Romania

3-6.09.2012

Application of laser based methods for the fabrication of polymeric transdermal drug-delivery systems incorporating captopril: Morphological characterization, A. Palla Papavlu, L. Rusen, V. Dinca, M. Dinescu

Poster

4.

ROMOPTO, , International Conference on Optics "Micro-to-Nano-Photonics III" Bucuresti, Romania

3-6.09.2012

Laser processing of soft materials: applications to controlled drug delivery, tissue engineering, sensing, I.A. Paun, A. Matei, V.C. Dinca, A. Palla Papavlu, C. Luculescu, V. Ion, A. Moldovan, T. Lippert, M. Dinescu 

Lectie invitata

5.

4th International Workshop: Current trends and advanced ellipsometry and all x-ray techniques for characterization of TCO, BIO, and other nanostructured materials

12-14.09.2012

MAPLE and LIFT soft techniques for organic material processing, V. Dinca, A. Palla Papavlu, A. Matei, I.A. Paun, M. Dinescu

Lectie invitata

6. E-MRS, Strasbourg, Franta
27-31.05.2013
Application of matrix-assisted pulsed laser evaporation for the
fabrication of polymeric transdermal drug-delivery system incorporating Captopril
, A. Palla-Papavlu, V. Dinca, M. Filipescu, C. Luculescu, L. Rusen, T. Lippert, M.
Dinescu

Poster

7. New Materials and
Devices Group,
Polytechnic School of the
University of Sao Paulo,
Brazilia
14.06.2012
Laser processing of soft
materials: An overview of
MAPLE and LIFT
, A. Palla Papavlu

Lectie invitata

8. ROMOPTO, International
Conference on Optics
"Micro-to-Nano-
Photonics III" Bucuresti,
Romania
3-6.09.2012
Application of laser based
methods for the fabrication of
polymeric transdermal drugdelivery
systems incorporating
captopril: Morphological
characterization
, A. Palla
Papavlu, L. Rusen, V. Dinca, M.
Dinescu

Poster 

9. ROMOPTO, ,
International Conference
on Optics "Micro-to-
Nano-Photonics III"
Bucuresti, Romania
3-6.09.2012
Laser processing of soft
materials: applications to
controlled drug delivery, tissue
engineering, sensing
, I.A. Paun,
A. Matei, V.C. Dinca, A. Palla
Papavlu, C. Luculescu, V. Ion, A.
Moldovan, T. Lippert, M. Dinescu

Lectie invitata

10. 4th International Workshop: Current
trends and advanced
ellipsometry and all x-ray
techniques for
characterization of TCO,
BIO, and other
nanostructured materials
12-14.09.2012
MAPLE and LIFT soft techniques for organic material processing,
V. Dinca, A. Palla Papavlu, A.
Matei, I.A. Paun, M. Dinescu

Lectie invitata

11. High Power Laser
Ablation HPLA/BEP, 21-
25.04.2014 Santa Fe,
New Mexico, SUA
Application of laser-based
methods for the fabrication of
Captopril transdermal patches
,
A. Palla Papavlu, V. Dinca, M.
Dinescu

Lectie invitata

12. European Materials
Research Society EMRS
26-30.05.2014
Lille, Franta
Fabrication of cardiovascular
drug deliery systems by matrix
assisted pulsed laser
evaporation
, A. Palla Papavlu, V.
Dinca, M. Dinescu

Poster

13. Conferinta nationala de
Imunologie, 2-4.10.2014
Bucuresti
Application of laser-based
methods for the fabrication of
Captopril transdermal patches,
A. Palla Papavlu
, I. Tirca, M.
Dinescu, L. Cremer, A. Calugaru,
E. Vlase, C. Coman

Poster

14. EMRS Autumn Meeting,
15-18.09.2014 Varsovia,
Polonia
Laser printing of carbon
nanotube networks for
chemiresistor sensor
applications
, A. Palla Papavlu, J.
Chen, A. Woakaun, T. Lippert, M.
Dinescu

Prezentare orala

 

Etapa I - 15.12.2011 (Raport stiintific)


Valoare etapa I:
106,250 lei

Etapa II - 15.12.2012 (Raport stiintific)


Valoare etapa II:
236,250 lei

Etapa III - 15.12.2013 (Raport stiintific)


Valoare etapa III:
248,750 lei

Etapa IV - 30.09.2014 (Raport stiintific)


Valoare etapa IV: 148,350 lei