Project name: TRANSDERMAL PATCH DEVELOPED BY LASER BASED METHODS FOR HYPERTENSIVE HEART DISEASE
Contract no. 41/05.10.2011
Project code: PN-II-RU-TE-2011-3-0267
PN II Program Name: Human Resources
Subprogram: Research projects for the stimulation of the forming of young independent research teams
Contracting authority: Executive Agency for Higher Education, Research, Development and Innovation Funding
Project director: Alexandra Palla Papavlu
Coordinator: National Institute for Lasers, Plasma, and Radiation Physics
This project aims at using an alternative technology, MAPLE, to prepare in a quick and one-step procedure a new generation transdermal patches with Captopril as active compound, for hypertensive heart diseases, in order to overcome its side effects by oral application. Such developments of an improved state-of-the-art transdermal patch by means of MAPLE promise to be a breakthrough in the field of medicine, biotechnology and polymer science.
The main objectives are sustained by intermediate objectives, corresponding to each year:
First year: First MAPLE experiments on the polymer and polymer blends chosen. Chemical and morphological characterization of the polymer thin films deposited.
Second year: MAPLE experiments on the polymers containing active substance. Analysis of the deposited material (morphology, chemical structure, adherence, contact angle measurements, determination of weight variation and thickness, determination of drug load in the films).
Third year: The in vivo and ex vivo tests on rats
Dr. Alexandra Palla-Papavlu – project director
Dr. Maria Dinescu – senior researcher
Dr. Andreea Matei – postdoctoral researcher
Dr. Valentina Dinca - postdoctoral researcher
Dr. Mihaela Filipescu – postdoctoral researcher
Dr. Catalin Luculescu – senior researcher
Antoniu Moldovan – PhD student
2. M. Dinescu, A. Matei, V. Dinca, A. Palla Papavlu, F. Di Pietrantonio, D. Cannata, M. Benetti, E. Verona, T. Lippert, Laser processing of organic materials: Applications in tissue engineering and chemical sensing, Romanian Reports in Physics, Vol. 65, pp 1091-1031 (2013)
3. A. Palla Papavlu, L. Rusen, V. Dinca, M. Filipescu, T. Lippert, M. Dinescu, Characterization of ethylcellulose and hydroxypropyl methylcellulose thin films deposited by matrix-assisted pulsed laser evaporation, Applied Surface Science 302: 87-91 (2014).
4. A. Palla-Papavlu, M. Filipescu, I. Tirca, T. Lippert, L. Cremer, A. Calugaru, E. Vlase, C. Coman, M. Dinescu, “Captopril transdermal patches prepared via laser-assisted method” – under review
First stage: 15.12.2011 (see Scientific report)
Value of first stage: 106,250 lei
Second stage: 15.12.2012 (see Scientific report)
Value of second stage: 236,250 lei
Third stage: 15.12.2013 (see Scientific report)
Value of third stage: 248,750 lei
Fourth stage: 30.09.2014 (see Scientific report)
Value of third stage: 148,350 lei